相关实验视频

Updated: Jun 21, 2025

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

结直肠癌肝脏转移中的免疫调节分子

Wei-Shuai Kong¹, Jia-Jun Li², Yu-Qing Deng¹

¹Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University, Guangzhou, 510060, China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, 510060, China.

|July 15, 2024

概括

大肠直肠癌肝脏转移 (CRLM) 涉及瘤微环境 (TME) 中的免疫抑制蛋白质. 了解这些分子是开发这种晚期癌症新疗法的关键.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

结肠直肠癌 (CRC) 是癌症死亡的主要原因,肝转移 (CRLM) 在50%的患者中发生,这意味着预后不佳.
肝脏的免疫耐受性创造了一个免疫抑制瘤微环境 (TME),有助于癌症的进展.
在CRLM中免疫逃避的机制尚未完全理解,特别是膜和分泌蛋白质的作用.

研究的目的:

审查最近发现的膜和分泌的蛋白质,参与在结直肠癌的TME内免疫逃避.
阐明这些蛋白质促进结直肠癌肝脏转移的特定机制.
讨论识别对CRLM免疫规避和潜在治疗点至关重要的蛋白质的策略.

主要方法:

关于结肠直肠癌肝脏转移的最近研究的文献综述.
对已识别的膜和分泌的蛋白质作为免疫调节分子的分析.
检查在瘤微环境中导致免疫逃避的机制.

主要成果:

已经确定了许多膜和分泌蛋白质在TME中具有免疫刺激和免疫抑制作用.
这些蛋白质在原发性CRC和转移性病变中显著影响免疫逃避,特别是在CRLM中.
突出了促进CRLM免疫逃避的特定蛋白质功能.

结论:

了解特定蛋白质在CRLM免疫规避中的作用对于改善患者的治疗结果至关重要.
查策略可以识别参与CRLM免疫逃避的关键蛋白质.
这些蛋白质代表了新型CRLM治疗的潜在治疗点.

关键词:

大肠直肠癌肝脏转移的转移.免疫调节分子免疫调节分子膜蛋白是一种膜蛋白质.分泌的蛋白质是分泌的蛋白质.瘤微环境是一个微环境.

更多相关视频

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...