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托利普和MUC5B调节环境NO₂对婴儿呼吸系统症状的影响

Olga Gorlanova¹, Céline Rüttimann¹, Andras Soti²

¹University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland; Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

|July 15, 2024

概括

婴儿呼吸道症状与空气污染暴露有关,MUC5B和TOLLIP基因的遗传变异影响了这种风险. 这些发现突出了特定基因多态化在调节对环境污染物的反应中的作用.

科学领域:

环境健康环境健康
遗传学遗传学是一种遗传学.
免疫学免疫学免疫学

背景情况:

MUC5B和TOLLIP基因区域与呼吸道防御和炎症有关,与呼吸道疾病有关.
暴露于空气污染是增加对呼吸道疾病易感性的已知危险因素.

研究的目的:

调查MUC5B和TOLLIP的遗传变异是否会改变空气污染物对婴儿免疫反应和呼吸系统症状的影响.
探索空气污染暴露与婴儿特定基因多态性之间的相互作用.

主要方法:

一项前性出生队列研究 (BILD) 包括359名健康的婴儿.
每周呼吸道症状得分是主要结果,每周空气污染物 (NO2,PM10) 暴露估计.
候选基因方法在MUC5B和TOLLIP中确定了10个单核酸多态 (SNP).
综合添加剂混合模型被用于分析,并使用肺上皮细胞进行体外验证.

主要成果:

在每周暴露于二氧化 (NO2) 和MUC5B和TOLLIP基因中的5个SNP之间发现了有关呼吸系统症状的显著相互作用.
具有特定TOLLIP SNPs (rs5744034,rs3793965,rs3750920) 中小等位基因的婴儿显示,随着NO2暴露的增加,呼吸系统症状风险增加.
在体外研究表明,TOLLIP下调细胞对柴油颗粒物和病毒刺激的细胞反应发生变化.

结论:

与空气污染相关的婴儿呼吸道症状可能受到MUC5B和TOLLIP SNP的遗传变异的影响.
实验室证据支持TOLLIP与空气污染之间的相互作用,验证了该研究的发现.

关键词:

空气污染大气污染基因与环境的相互作用婴儿时期的婴儿时期在MUC5B中,MUC5B是MUC5B.呼吸道症状呼吸道症状郁金香:一个郁金香.

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