生命的重要八个,遗传易感性和发生的心律失常:基于人口的前性队列研究
Da-Chuan Guo1, Zhi-Teng Chen2, Xiang Wang3
1Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; Graduate School, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The Canadian journal of cardiology
|July 15, 2024
概括
保持理想的心血管健康 (CVH) 显著降低了发展心房动,心室心律不整和胸腔心律不整的风险. 采用更健康的生活方式选择,以生命的基本8 (LE8) 度量衡量,对于预防心律失常至关重要.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 公共卫生 公共卫生
背景情况:
- 理想的心血管健康 (CVH) 与心血管疾病 (CVD) 风险降低有关.
- 尽管如此,CVH与心律失常之间的关联仍然不清楚.
- 这项研究研究了CVH对心房动 (AF),心室心律不整和胸节律不整等心律不整的影响.
研究的目的:
- 检查心血管健康和患心律不整的风险之间的关系.
- 确定较高的CVH水平是否与较低的AF发病率,心室心律不整以及胸节律不整有关.
- 评估生活必需8 (LE8) 指标对心律失常风险的影响.
主要方法:
- 一项前性队列研究,利用英国生物库287264名参与者的数据.
- 考克斯回归模型分析了CVH水平 (LE8指标) 和心律失常之间的关联.
- 参与者最初没有心律失常.
主要成果:
- 在12.8年的时间里,记录了16,802例发生性心肌梗塞,2186例心室节律失常和4128例心室节律失常.
- 高水平的CVH与显著降低AF (HR 0.63),心室心律失常 (HR 0.48) 和肌节律失常 (HR 0.64) 的风险有关.
- 每个LE8得分的SD增加都将AF风险降低15%,心室失常率降低21%,胸失常率降低13%.
结论:
- 通过LE8指标评估的较高水平的CVH与显著降低AF,心室节律失常和胸节律失常的风险有关.
- 保持理想的心血管健康是防止常见心律失常的保护因素.
- 这些发现强调了促进CVH用于心律失常预防的重要性.
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