微生物组的宇宙:对健康,疾病和癌症治疗的影响
Zsuzsánna Réthi-Nagy1, Szilvia Juhász1
1Hungarian Centre of Excellence for Molecular Medicine, Cancer Microbiome Core Group, Budapesti út 9, Szeged H-6728, Hungary.
Journal of biotechnology
|July 15, 2024
概括
人类微生物组会影响健康,而这些微生物组的破坏 (失生症) 与癌症等疾病有关. 诸如益生菌和便微生物群移植 (FMT) 等干预措施可以帮助重新平衡微生物群,以改善健康结果.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 人类微生物组是一个复杂的微生物生态系统,影响健康.
- 进步揭示了微生物群落在以前无菌的网站.
- 肠道微生物群对于宿主新陈代谢和免疫功能至关重要.
研究的目的:
- 突出微生物群在健康和疾病中的作用.
- 讨论失生症和抗生素使用的影响.
- 探索微生物组再平衡的治疗策略.
主要方法:
- 关于人类微生物组的当前科学文献的综述.
- 对测序技术及其影响的分析.
- 对治疗失生症的治疗干预措施的检查.
主要成果:
- 失生症与癌症,炎症性肠道疾病和代谢障碍有关.
- 抗生素可以破坏肠道微生物社区.
- 益生菌,FMT和基于细菌的疗法显示出重新平衡的希望.
结论:
- 针对微生物群是对抗癌症等疾病的关键.
- 了解饮食-微生物组-癌症相互作用对于个性化医学至关重要.
- 多学科合作对于微生物组研究的临床转化至关重要.
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