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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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粒子弧线疗法:现状和潜在的潜力

Stewart Mein1, Sophie Wuyckens2, Xiaoqiang Li3

  • 1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA; Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
|July 15, 2024
PubMed
概括
此摘要是机器生成的。

使用像质子和碳离子这样的带电粒子束的粒子弧疗法正在获得临床兴趣. 本报告概述了其未来实施的物理,放射生物学和临床途径.

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 微粒疗法是一种微粒疗法.

背景情况:

  • 对带电粒子束 (质子,碳离子) 的弧形传递技术越来越感兴趣.
  • 需要明确一条通往粒子弧疗法的临床实施的道路.
  • 跨学科合作对于推进新型辐射技术的重要性.

研究的目的:

  • 报告欧洲放射治疗和瘤学会 (ESTRO) 2022年关于粒子弧线疗法的物理研讨会的观点.
  • 为临床可行的质子,碳和其他离子弧治疗提供前景和愿景.
  • 促进社区对粒子弧疗法的物理,放射生物学和临床原理的理解.

主要方法:

  • 来自ESTRO 2022物理研讨会的见解的巩固.
  • 涉及行业,学术界和临床研究和开发的合作努力.
  • 信息在治疗计划,治疗和临床前景方面的结构化呈现.

主要成果:

  • 介绍了粒子弧疗法的当前科学格局和未来前景.
  • 确定治疗规划和提供发展的关键领域.
  • 讨论离子束弧疗法的临床潜力和考虑.

结论:

  • 粒子弧疗法代表了辐射瘤学的有前途的进步.
  • 持续的合作对于克服技术和临床挑战至关重要.
  • 这项工作提供了一个基本的概述,以指导该领域的未来研究和开发.