GRAPPA辩论:针对性小分子与生物药物作为中度至重度牛皮的常规疗法后的第一线系统疗法
Wilson Liao1, April W Armstrong2, Kristina Callis Duffin3
1W. Liao, MD, Department of Dermatology, University of California San Francisco, San Francisco, California; wilson.liao@ucsf.edu.
The Journal of rheumatology
|July 15, 2024
概括
对于中度至严重的牛皮 (PsO),口服小分子药物和生物疗法都有明显的优势. 治疗选择取决于个体患者的需要和医疗保健系统的考虑.
科学领域:
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮 (PsO) 是一种慢性炎症疾病,在传统疗法失败后需要有效治疗.
- 生物疗法和口服小分子向药物代表了中度至重度PsO的先进治疗选择.
研究的目的:
- 讨论和对比口服向小分子药物的第一线使用与中度至重度牛皮的生物治疗.
- 在有效性,安全性,患者偏好,成本和全球健康的背景下,评估每个治疗方法的优缺点.
主要方法:
- 在2023年牛皮和牛皮关节炎研究和评估小组 (GRAPPA) 年会上采用辩论格式.
- 提出了支持和反对口服小分子药物和生物疗法的第一线使用的论点.
主要成果:
- 小分子药物的论点:良好的疗效,安全性,患者偏好,成本节省,全球健康公平性和环境效益.
- 生物制剂的论点:卓越的疗效,卓越的安全性,长期数据,儿科批准和潜在的并发症益处.
结论:
- 口服小分子药物和生物疗法都是中度至重度牛皮的有价值的治疗选择.
- 小分子和生物制剂之间的最佳选择应根据患者特定因素和医疗保健系统资源进行个性化.
相关概念视频
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
166
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
166
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
128
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
128
01:28Drug Therapy
41
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
41
01:28Biopharmaceutics and Pharmacokinetics: Overview
1.9K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
1.9K
01:21Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
1.3K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.3K
01:26Psychosis: Goals of Pharmacotherapy
119
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
119