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在患者的代谢和脂质组的变化与内置支架置症

Ziqi Xu¹, Chenye Mou¹, Renjie Ji¹

¹Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

CNS neuroscience & therapeutics

|July 15, 2024

概括

静脉静脉缩 (ISR) 涉及到新陈代谢的改变,特别是在氨酸和氨酸途径中. 醇硫酸盐和酸糖胺 (38:4) 显示出作为生物标志物的承诺,用于识别ISR.

科学领域:

心血管研究研究心血管研究
代谢学代谢学代谢学
生物标志物发现发现

背景情况:

静脉静脉阻塞 (ISR) 阻碍了血液流动,可能导致中风.
内皮细胞的过度增殖和血栓形成是ISR的关键原因,改变了血管内代谢.
在ISR中发生的代谢变化仍然不太了解.

研究的目的:

为了描述ISR和非静脉缩 (NR) 患者之间的血清代谢组差异.
确定涉及ISR的关键代谢途径.
探索ISR检测的潜在生物标志物.

主要方法:

血清代谢和脂质组学分析.
在ISR和NR患者组之间的代谢资料的比较.
识别显著改变的代谢物和途径.

主要成果:

半氨酸和氨酸通路在ISR组中表现出增加的活性.
在ISR患者中,高水平的N-甲基-l-甲氨酸,L-甲氨酸,2-黄酸,Pyruvate和Taurocholate.
改变的脂质样本 (增加的酸丁胆和酸丁,减少的三糖醇),并确定了硫酸盐和PS{38:4}作为潜在的生物标志物 (AUC>0.85).

结论:

在ISR患者中存在显著的代谢变化.
氨酸和氨酸通路在ISR中受到显著影响.
硫酸盐和PS{38:4) 显示出作为ISR.38的诊断生物标志物的潜力.

关键词:

生物标志物生物标志物体内静脉复缩 (英语:in-stent restenosis) 是一种静脉复缩.脂质组的类型代谢生物组的代谢生物组甲氨酸的使用方法

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