使用脑网络分析预测主观认知衰退的个体的疾病进展
Simin Deng1,2, Si Tan3, Xiaojing Song3
1School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong, China.
CNS neuroscience & therapeutics
|July 15, 2024
概括
在逐渐和稳定的主观认知衰退 (SCD) 之间存在大脑网络差异. 右小脑Crus I可能有助于区分渐进的SCD和稳定的SCD,有助于早期诊断.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 主观认知衰退 (SCD) 是痴呆症的前体.
- 区分渐进型 (P-SCD) 和稳定的 (S-SCD) SCD 形式对于及时干预至关重要.
- 基线大脑功能网络特征可能为SCD进展提供见解.
研究的目的:
- 为了研究P-SCD和S-SCD个体之间的基线大脑功能网络差异.
- 为了确定区分P-SCD和S-SCD的潜在生物标志物.
主要方法:
- 使用了阿尔茨海默病神经成像计划 (ADNI) 数据库.
- 包括39名S-SCD,15名P-SCD和45名认知正常 (CN) 参与者.
- 使用使用AAL模板构建的大脑功能网络的图形理论分析.
主要成果:
- S-SCD组显示增强的小世界性和加速的信息传输.
- 在S-SCD组中观察到双边后 cingulate gyri (PCG) 的连接性增加.
- 与S-SCD相比,P-SCD组在右小脑Crus I中的节点局部效率降低.
结论:
- 大脑功能网络的显著基线差异区分P-SCD和S-SCD.
- 右小脑Crus I显示出作为区分P-SCD和S-SCD的关键区域的潜力.
更多相关视频
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.9K
09:06Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
12.1K
相关概念视频
01:37Neural Regulation
39.3K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.3K
01:26Alzheimer's Disease: Overview
461
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
461