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Updated: Jun 21, 2025

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通过LINE1介导的雄激素受体转录的表观遗传抑制导致雄激素不敏感综合征

Jelena Pozojevic1, Radhika Sivaprasad2, Joshua Laß3

  • 1Institute of Human Genetics, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany. jelena.pozojevic@uksh.de.

Scientific reports
|July 15, 2024
PubMed
概括

确定了一种导致雄激素不敏感综合征 (AIS) 的新病因:LINE1逆转移素插入雄激素受体 (AR) 基因. 这种插入会破坏AR功能,导致46,XY个体的低病毒化.

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