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Updated: Jun 21, 2025

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自适配器TRIAD3A通过嵌套相位分离促进纤维化

Jiechao Zhou1, Yang 'an Chuang1,2,3, Javier Redding-Ochoa4

  • 1Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature cell biology
|July 15, 2024
PubMed
概括

一种E3结合酶TRIAD3A,作为一种自适应器,降解蛋白聚合物. 在TRIAD3A的突变加剧神经退行,突出其在阿尔茨海默氏症等疾病中的作用.

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