BACH2调节TH17细胞中调节性和促炎性染色质状态的多样化

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Updated: Jun 21, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

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Pratiksha I Thakore1,2, Alexandra Schnell1,3,4, Linglin Huang3,5,6

  • 1Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature immunology
|July 15, 2024
PubMed
概括

产生中白素-17 (IL-17) 的辅助T (TH17) 细胞具有不同的致病和非致病形式. 这项研究揭示了关键的调节通路和染色质差异,确定BACH2是TH17细胞功能和自身免疫的关键因素.

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