高血糖变异性可能预测手术时自发小脑出血的患者的不良结果:一项回顾性研究
Lei Cheng1, Guifeng Yang2, Jian Sun1,3
1Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
BMC neurology
|July 15, 2024
概括
高血糖变化与为自发小脑出血进行手术的患者的不良结果有关. 这一发现强调了监测葡萄糖水平的重要性,以改善患者的预后.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 外科手术的结果
背景情况:
- 血糖 (BG) 变异性升高是各种疾病中不良结果的已知危险因素.
- 在接受手术的自发小脑出血 (SCH) 患者中,BG变异的预后意义仍在调查中.
研究的目的:
- 调查BG变异性和手术后SCH患者的临床结果之间的关联.
- 确定BG变异性是否是该患者队列中预后不佳的独立预测因素.
主要方法:
- 一项回顾性队列研究包括115名被诊断患有SCH的患者,他们接受了手术治疗.
- 使用序列BG测量的标准偏差 (SD) 来量化血糖变化,该标准偏差是在治疗后的前7天内测量.
- 在6个月后,使用修改的兰金尺度 (mRS) 评估了临床结果.
主要成果:
- 该研究确定了115名SCH患者,其中26.96%的患者经历了不良结果 (mRS3-6),死亡率为10.43%.
- 多变量后勤回归显示,BG的变化 (BG的SD),格拉斯哥昏迷表 (GCS) 评分和血液瘤体积是结果的重要预测因素.
- 对于BG的波动性,ROC曲线下的面积为0.911,这表明差结果的预测准确度很高.
结论:
- 高血糖变异性与SCH患者进行手术的6个月不良结果独立相关.
- 监测和管理BG变异性可能对改善这些患者的预后至关重要.
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