饮食总抗氧化能力与膝关节骨关节炎之间的关联:伊朗人口中的病例控制研究
Farshad Amirkhizi1, Soudabeh Hamedi-Shahraki2, Mehran Rahimlou3,4
1Department of Nutrition, Faculty of Public Health, Zabol University of Medical Sciences, Zabol, Iran.
BMC musculoskeletal disorders
|July 15, 2024
概括
更高的饮食总抗氧化能力 (DTAC) 与明显降低患膝关节关节炎 (KOA) 的几率有关. 这一发现表明抗氧化剂在预防KOA方面可能起着保护作用.
科学领域:
- 营养科学 营养科学
- 类风湿病学 类风湿病学
- 流行病学 流行病学
背景情况:
- 膝关节关节炎 (KOA) 是一种广泛的退行性关节疾病,引起疼痛和残疾,特别是在老年人中.
- 目前对KOA的治疗主要是治疗症状,而不是解决潜在原因.
- 对于可改变的生活方式因素,如饮食,可能影响KOA发展的理解有限.
研究的目的:
- 调查饮食总抗氧化能力 (DTAC) 与膝关节骨关节炎 (KOA) 的患病率之间的联系.
- 在伊朗人口中探索饮食中抗氧化剂对KOA的潜在保护作用.
主要方法:
- 一项病例控制研究,涉及105名被诊断患有KOA的患者和210名健康对照.
- 使用美国风湿病学学院的标准确认了KOA诊断.
- 饮食总抗氧化能力 (DTAC) 评估使用降铁抗氧化能力 (FRAP) 方法.
主要成果:
- 在DTAC的最高四分位数中,与最低四分位数 (OR:0.29,P < 0.001) 相比,Koa患病的可能性降低了71%.
- 这种反向关联在调整了诸如年龄,BMI,体力活动和吸烟等混因素后仍然存在.
- 较高的DTAC的保护作用在两性中都被观察到,但在男性中更为明显.
结论:
- 饮食总抗氧化能力 (DTAC) 和膝关节关节炎 (KOA) 之间存在显著的反向相关性.
- 较高的抗氧化剂摄入量可能在预防或发展KOA中发挥保护作用.
- 需要进一步的研究来探索饮食中抗氧化剂在KOA管理中的临床影响.
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