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脑髓母细胞瘤中与circRNA和lncRNA相关的竞争性内源性RNA网络:一个范围审查
Fatemeh Nejadi Orang1, Mahdi Abdoli Shadbad2
1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer cell international
|July 15, 2024
概括
这项研究审查了圆形RNA (circRNA) 和长非编码RNA (lncRNA) 在脑细胞瘤中竞争的内源RNA (ceRNA) 网络. 针对这些网络为儿科中枢神经系统 (CNS) 癌症提供了新的治疗途径.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 脑膜母细胞瘤是一种常见的儿科中枢神经系统 (CNS) 恶性瘤.
- 目前的治疗方法,如手术和化学放射治疗,具有显著的副作用.
- 了解脑髓母细胞瘤生物学对于开发新疗法至关重要.
研究的目的:
- 在脑细胞瘤中全面研究circRNA和lncRNA相关的竞争性内源性RNA (ceRNA) 网络.
- 审查这些网络对微RNA (miRNA) 和信使RNA (mRNA) 表达的影响.
- 在这些调节途径中识别潜在的治疗点.
主要方法:
- 在2023年9月16日之前对Web of Science,PubMed,Scopus和Embase的系统文献搜索.
- 遵守PRISMA-ScR声明进行系统审查.
- 对已识别的circRNAs和lncRNAs参与脑细胞瘤ceRNA网络的分析.
主要成果:
- 确定了致癌性 lncRNAs:HOTAIR,NEAT1,linc-NeD125,HHIP-AS1,CRNDE,以及TP73-AS1. 这三种类型的 lncRNAs 已经被发现.
- 确定了抑制瘤的 lncRNA: Nkx2-2as.
- 已发现的致癌性circRNAs:CircSKA3和circRNA_103128.8. 这两种circRNAs都具有致癌性.
- 这些分子形成ceRNA网络,影响脑髓母细胞瘤中的基因表达.
结论:
- 与circRNA和lncRNA相关的ceRNA网络显著影响中枢细胞瘤中的miRNA和mRNA表达.
- 这些网络涉及到各种脑髓母细胞瘤信号通路.
- 向致癌性ceRNA网络并增强瘤抑制性网络为脑髓母细胞瘤提供了有前途的治疗策略.
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