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在患有支气管切除症的患者中,非结核性真菌细菌感染的表型特征
Assaf Frajman1,2, Shimon Izhakian3,4, Ori Mekiten1,2
1Pulmonary Institute, Rabin Medical Center - Beilinson Hospital, 39 Jabotinksy St, Petach Tikva, 4941492, Israel.
Respiratory research
|July 15, 2024
概括
支气管切除症患者的非结核性真菌菌 (NTM) 感染正在增加. 具有NTM阳性的个体通常是老年,女性,并表现出更严重的疾病指标,这表明查需要一个不同的临床表型.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 医学微生物学 医学微生物学
背景情况:
- 由于非结核菌菌 (NTM) 肺部感染,支气管切除症患者的全球死亡率和发病率不断上升.
- 需要确定NTM阳性支气管切除症患者的特定特征.
研究的目的:
- 定义NTM阳性支气管切除症患者的临床,实验室,功能和放射学表型.
主要方法:
- 成年支气管切除症患者进行支气管镜检查的回顾性观察性研究 (2007-2020年).
- 在NTM-阳性和NTM-阴性组之间比较临床,实验室,肺功能和放射学数据.
主要成果:
- 阳性NTM患者年龄较大,主要是女性,GERD和粘液活性药物使用率较高.
- 在NTM阳性个体中观察到较低的BMI,白蛋白,淋巴细胞/乙氨基酸计数和较差的肺功能 (FEV1,FVC,DLCO).
- 在NTM阳性组中,增加了支气管切除的参与 (双边,上叶,叶数) 和更多的恶化. 年龄较大,BMI较低,以及更多参与的叶片预测了NTM感染.
结论:
- 支气管切除和NTM感染的患者呈现出独特的表型:年长,女性,具有更严重的临床,实验室,功能和放射性参数.
- 这种已识别的表型可以帮助查和早期检测NTM疾病在高风险的支气管病患者.
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