在完全形成胚胎囊后,胚胎囊的多次崩是形积分病的独立风险因素 - - 这是一项基于人工智能和人工验证的研究
1Reproductive Medicine Center, Tongji Hospital, Tongji Medical Colleine, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Reproductive biology and endocrinology : RB&E
|July 15, 2024
概括
完全形成 (tB) 后的多个胚胎囊崩与更高的形积分率有关,这表明它.
科学领域:
- 生殖生物学 生殖生物学
- 胚胎学 胚胎学
- 遗传学 是一个遗传学.
背景情况:
- 胚胎囊塌是胚胎质量的潜在指标.
- 之前的研究表明,崩,动脉积症和不良结果之间存在联系,但需要进一步调查.
- 人工智能 (AI) 可以量化胚胎囊崩的特征.
研究的目的:
- 使用人工智能来描述胚胎囊塌的特征.
- 探索胚胎囊崩,胚胎化和临床结果之间的关联.
主要方法:
- 对来自1071个时间延迟植入前遗传测试周期的3288个活检胚胎细胞的观察性研究.
- 人工智能分析了时差视频,以量化崩事件 (时间,持续时间,收缩).
- 来自euploid和aneuploid胚胎的数据被分析为与崩和临床结果的关联.
主要成果:
- 在完全胚胎囊形成 (tB) 后的多次崩与形积分率的增加相关 (OR=2.597,P=0.001).
- 体胚胎,特别是单体胚胎和具有亚染色体缺失的胚胎,在tB之后出现更高的崩率.
- 胚胎囊塌与发育延迟和胚胎质量降低有关,但与怀孕或活产率无关.
结论:
- 胚胎囊塌是发育过程中常见的事件.
- 在tB之后的多次崩可以独立地预测形积分症.
- 临床医生和胚胎学家在选择移植胚胎时应考虑胚胎囊塌.
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