子宫内膜衰老是由白蛋白17受体B信号传递介导的
Keiko Kawamura1, Yumiko Matsumura1, Teruhiko Kawamura1
1Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.
Cell communication and signaling : CCS
|July 15, 2024
概括
介素17受体B (IL17RB) 与子宫内膜衰老和细胞衰老有关. 过度表达IL17RB和随后的IL1β信号通过JNK通路促进衰老,影响子宫环境.
科学领域:
- 生殖生物学 生殖生物学
- 细胞衰老 细胞衰老
- 分子内分泌学分子内分泌学
背景情况:
- 介素17受体B (IL17RB) 被确定为子宫内膜衰老的潜在标志物.
- 在子宫内膜中IL17RB的功能在很大程度上仍然未被描述.
- 以前的研究将IL17RB与其他组织的炎症和恶性瘤联系起来.
研究的目的:
- 研究IL17RB在人类子宫内膜中的功能作用.
- 为了确定与年龄相关的IL17RB过度表达对子宫环境的影响.
- 阐明参与IL17RB介导子宫内膜变化的信号通路.
主要方法:
- 利用了不朽化的人类子宫内膜腺上皮细胞 (hEM),这些细胞被设计成表达IL17RB.
- 从子宫切除组织中获得的确定的患者衍生子宫内膜器官器官 (EO).
- 分析了RNA测序数据,并研究了JNK通路对有机体形成能力的影响.
主要成果:
- 通过交白素17B (IL17B) 激活IL17RB,上调NF-κB信号传递,增加与衰老相关的分泌表型 (SASP) 因素 (IL6,IL8,IL1β).
- 介质素1β (IL1β) 抑制了子宫内膜器官成体的生长和增加了p21表达,表明衰老.
- 该JNK通路与与年龄相关的IL17RB表达有关,其抑制恢复了有机体形成能力.
结论:
- 在子宫内膜腺上皮质中的IL17RB表达与细胞衰老相关.
- 通过IL17RB上调的IL1β,通过JNK通路驱动子宫内膜衰老.
- 这项研究提供了关于子宫内膜衰老的分子机制的见解.
关键词:
衰老的衰老 衰老的衰老子宫内膜衰老 子宫内膜衰老在IL17B的研究中,IL17B在 IL17RB 中, IL17RB 是 IL17RB一个IL1ββ.在JNK中,JNK就是JNK.巨细胞是一个巨细胞.在 NF-κBB 中.有机器人机器人机器人机器人在 SASP 找 SASP更多相关视频
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