铜诱导的毒性通过调节Atox1在小鼠的周期1控制

Sarah Tominaga1,2, Hiroki Yoshioka3,4,5, Satoshi Yokota6

  • 1Graduate School of Pharmaceutical Sciences, Kinjo Gakuin University, 2-1723 Omori, Moriyamaku, Nagoya, Aichi 463-8521, Japan.

概括

接触铜会导致细胞受损,但时钟基因Per1可以防止这种毒性. 过度表达Per1可以通过调节铜伴侣Atox1.1.来降低铜水平和细胞死亡.