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Updated: Jun 21, 2025

Visualization and Quantification of TGFβ/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay
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由于HLA-B27的表达改变了TGFβ信号通路,导致与脊椎关节炎相关的致病后果

Marc Lauraine1,2, Maxence de Taffin de Tilques3, Dganit Melamed-Kadosh4

  • 1Infection & Inflammation, UMR 1173, Inserm, UVSQ, Université Paris Saclay, 2 avenue de la Source de la Bièvre, Montigny-le-Bretonneux, 78180, France.

Arthritis research & therapy
|July 15, 2024
PubMed
概括

人类白细胞抗原B27 (HLA-B27) 蛋白质破坏了Drosophila和老鼠的转化生长因子β (TGFβ) 信号通路. 这种干扰可能通过影响T细胞分化来解释其与脊椎关节炎 (SpA) 的关联.

关键词:
这种植物是Drosophila.通过BMP/TGFβ途径.在CD4+T细胞中.这就是HLA-B27的原因.体体 (Peptidome) 是一种体体.鼠标 鼠标 鼠标 鼠标脊椎关节炎是一种脊柱性关节炎.

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