Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

697
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
697

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same authorSame journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same author

A temporal map of B cell diversification mechanisms in mice.

Nature immunology·2026
Same author

Coupling dead cell recognition to Fcγ receptors augments anticancer immunity.

Nature cancer·2026
Same author

Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity.

Immunity·2026
Same author

The GFI1-FOXO1 axis regulates NK cell maturation and function.

Nature communications·2026
Same author

Feature-preserving manifold approximation and projection to analyze single-cell data.

Nature computational science·2026

相关实验视频

Updated: Jun 21, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

在自身免疫性中对克隆多样性的计算估计.

Zewen Kelvin Tuong1,2, Rohan van der Merwe1, Pablo F Canete1,2

  • 1Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Immunology and cell biology
|July 16, 2024
PubMed
概括

使用单细胞测序测量淋巴细胞多样性对于理解适应性免疫和自身免疫性疾病至关重要. 准确的多样性指标有助于发现新疗法和有效诊断疾病.

关键词:
这是自身免疫性疾病.多样性的多样性多样性的多样性免疫系统的曲目.一个单细胞的单细胞.

更多相关视频

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

26.7K
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.2K

相关实验视频

Last Updated: Jun 21, 2025

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

26.7K
T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
08:59

T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

Published on: January 12, 2021

8.2K

科学领域:

  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.
  • 计算生物学 计算生物学

背景情况:

  • 适应性免疫依赖于淋巴细胞的多样性来对抗病原体.
  • T细胞受体 (TCR) 和B细胞受体 (BCR) 多样性的改变与自身免疫有关.
  • 对免疫学研究来说,量化免疫谱的多样性是必不可少的.

研究的目的:

  • 通过单细胞TCR和BCR测序测量淋巴细胞多样性的现有方法进行审查.
  • 突出多样性评估在理解适应性免疫和自身免疫性疾病方面的重要性.
  • 讨论多样性指标在自身免疫性疾病发现和治疗开发中的作用.

主要方法:

  • 单细胞T细胞受体 (TCR) 的测序.
  • 单细胞B细胞受体 (BCR) 的测序.
  • 多样性估计算法和计算分析.

主要成果:

  • 单细胞测序提供了高分辨率的数据用于免疫谱系分析.
  • 多样性指标可以区分保护性免疫和自身免疫状态.
  • 案例研究表明,在自身免疫性疾病的理解和治疗创新方面取得了突破.

结论:

  • 精确测量淋巴细胞多样性对于促进免疫学的发展至关重要.
  • 单细胞测序为评估免疫谱的复杂性提供了强大的工具.
  • 了解免疫多样性是开发有针对性的自身免疫疗法的关键.