在实体器官移植接受者中评估口腔简单疹病毒的传播:试点研究
Molly D Fischer1, Margaret L Green2, Stacy Selke3
1Department of Epidemiology, University of Washington, Seattle, Washington, USA.
概括
大多数实体器官移植接受者通过口腔传播简单疹病毒 (HSV),往往没有症状. 自行采集的拭子可用于监测这些患者的HSV重新激活.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
背景情况:
- 简单疹病毒 (HSV) 的重新激活在固体器官移植 (SOT) 后免疫抑制期间很常见.
- 在慢性免疫抑制的SOT接受者中,无症状的病毒分泌动力学尚不清楚.
- 这项研究调查了非抗病毒预防的SOT接受者口服HSV泄漏.
研究的目的:
- 鉴定口腔简单疹病毒 (HSV) 在固体器官移植 (SOT) 受体中流出的特征.
- 评估患者自行采集口腔拭子用于HSV监测的可行性.
- 要了解这个人群中无症状的HSV流产的频率和持续时间.
主要方法:
- 15名HSV-1血清阳性SOT接收者 (8个肝脏,7个脏) 自行采集口腔抽样,每天3次,持续6周.
- 参与者在日常日记中记录口腔症状或病变.
- 在收集的口腔抹布上进行了HSV量化.
主要成果:
- 对采样的高度坚持 (中位数为122个抽样/人).
- 80%的参与者至少经历过一次口服HSV泄漏事件 (中位数为8.9%).
- 75%的脱皮事件无症状,平均持续时间为21.8小时.
结论:
- 在SOT接收者中,口服HSV流放很常见,通常没有症状.
- 患者自行收集口腔抹布是监测HSV的一种可行的方法.
- 研究结果表明,每天两次采样可能会检测出大多数流产发作,为未来的研究设计提供信息.
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