对于接受血造细胞移植的儿科患者的Pneumocystis jirovecii预防实践的差异
Amanda Lipsitt1, Diego R Hijano2, Jose A Ferrolino2
1Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
血造细胞移植接受者通常不会接受Pneumocystis jirovecii肺炎 (PJP) 预防,因为担心trimethoprim/sulfamethoxazole (TMP-SMX) 骨髓毒性. 需要进一步的研究来评估TMP-SMXX.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 移植医学 移植医学
背景情况:
- 肺囊 (PJP) 肺炎是受血造细胞移植 (HCT) 接受者的重大风险.
- 有效的预防对于在这个脆弱人群中预防PJP至关重要.
研究的目的:
- 调查北美HCT中心关于他们的PJP预防实践.
- 确定常见的预防药物和时间,特别是关于trimethoprim/sulfamethoxazole (TMP-SMX).
主要方法:
- 一项调查分发给北美各地的HCT中心.
- 评估了PJP预防的实践,包括药物选择和施用时间.
主要成果:
- 静脉注射 (IV) 胺素 (29.6%) 和吸入式胺素 (14.8%) 是常见的预防选择.
- 37%的机构从TMP-SMX转向后调节,44%的机构拒绝了移植前的预防.
- 由于骨髓毒性问题,TMP-SMX在移植前经常被避免使用.
结论:
- 目前在HCT接受者的PJP预防实践各不相同.
- 对TMP-SMX骨髓毒性的担忧影响了其使用,尽管它是首选的药物.
- 需要进一步评估TMP-SMX对植入物的影响.
更多相关视频
08:52Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
相关概念视频
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
