Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Female PMHS Thoracic Biomechanical Response Corridors with Preliminary Consideration of the Influence of Breast Tissue in Frontal Impacts.

Stapp car crash journal·2026

Same author

Past-Year Emergency Department Utilization Patterns Among Suicide Decedents: Characterizing At-Risk Patient Populations.

Annals of emergency medicine·2026

Same author

Patient-level predictors of unspecified head injury coding in traumatic brain injury-related population-based emergency department visits.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2025

Same author

Implications of case definition selection on traumatic brain injury trends: A controlled interrupted time-series analysis of North Carolina emergency department data.

Annals of epidemiology·2025

Same author

Improving the Performance of a Syndromic Surveillance Definition for Sexual Violence.

Journal of public health management and practice : JPHMP·2025

Same author

Comparison of Bending Properties in Paired Human Ribs with and without Costal Cartilage.

Stapp car crash journal·2024

Search research articles

相关实验视频

Updated: Jun 21, 2025

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

在生物力学测试中用于死后脑组织的防腐剂:试点研究

Ann Mallory^1,2, Alaine Wetli³, Lucas M Neuroth⁴

¹National Highway Traffic Safety Administration, Vehicle Research and Test Center, Applied Biomechanics Division, East Liberty, Ohio, USA.

Journal of anatomy

|July 16, 2024

概括

这项研究研究了死后人类受试者 (PMHS) 脑组织的防腐剂. 碳酸在生物力学测试期间减少组织分解,保持伤害研究的组织特性方面表现有前途.

关键词:

抗生素抗生素是一种抗生素.抗微生物药物是一种抗菌药物.生物力学生物力学大脑组织硬性脑组织硬性碳酸二碳酸的使用方法储存温度储存温度储存温度组织防腐剂组织防腐剂

更多相关视频

Preparation of Non-human Primate Brain Tissue for Pre-embedding Immunohistochemistry and Electron Microscopy

Preparation of Non-human Primate Brain Tissue for Pre-embedding Immunohistochemistry and Electron Microscopy

Published on: April 3, 2017

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

相关实验视频

Last Updated: Jun 21, 2025

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

Preparation of Non-human Primate Brain Tissue for Pre-embedding Immunohistochemistry and Electron Microscopy

Preparation of Non-human Primate Brain Tissue for Pre-embedding Immunohistochemistry and Electron Microscopy

Published on: April 3, 2017

Lipidomics and Transcriptomics in Neurological Diseases

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

科学领域:

生物机械工程生物机械工程
神经科学是一个神经科学.
法医科学法医科学法医科学

背景情况:

死后人类受试者 (PMHS) 研究对于了解机动车辆事故中脑损伤机制至关重要.
尸体后组织降解损害了生物力学测试的准确性,限制了其与体内条件的相关性.
开发有效的保存方法对于保持大脑组织的完整性至关重要.

研究的目的:

评估不同防腐剂溶液在缓解死后脑组织退化的有效性.
为了确定潜在的防腐剂,可以保持大脑组织的机械特性,用于生物机械分析.
为未来的研究提供信息,以提高脑损伤研究中PMHS数据的可靠性.

主要方法:

在存储在各种人工脑脊髓液 (ACSF) 溶液中的大脑样本中的组织分解的定性评估10°C.
收获后立即对脑组织样本进行压缩度测试,并在不同ACSF溶液中储存24小时后进行压缩度测试.
使用多重线性回归来比较基于储存溶液和收获位置的组织刚度的统计分析.

主要成果:

用抗生素/抗真菌药物和碳酸存储在ACSF中的样本显示质量较低的组织分解.
与新鲜样本相比,在ACSF或ACSF与抗生素/抗真菌药物储存24小时的大脑组织的硬度显著降低.
在含有二碳酸的ACSF溶液中储存的组织保持了与立即采集的样本相比的硬度.
在额叶和顶叶样本之间没有发现显著的硬度差异.

结论:

碳酸在生物机械测试中显示出作为一种防腐剂的潜力,可以减少死后脑组织的恶化.
保护大脑组织的特性对于提高对脑损伤机制和头部损伤耐受性的理解至关重要.
需要进一步的研究来评估二碳酸在各种条件下和全头测试中的有效性.