从2018年到2023年,赛马药物和兴奋剂控制方面的分析进展
Bob Gray1, Katy Lubbock1, Catherine Love1
1LGC Ltd, Cambridgeshire, UK.
Drug testing and analysis
|July 16, 2024
概括
用于赛马药物和兴奋剂控制的分析方法正在迅速发展. 本综述涵盖了药物检测,样本准备和基因兴奋剂等新兴威胁的关键发展.
科学领域:
- 分析化学 分析化学
- 法医科学 法医科学 法医科学
- 兽医科学 兽医科学 兽医科学
背景情况:
- 赛马反兴奋剂和药物控制依赖于复杂的,不断发展的分析方法.
- 实验室策略受到当地监管,经济和科学因素的影响.
- 持续改进查对于应对新出现的威胁和加强服务至关重要.
研究的目的:
- 审查赛马药物和兴奋剂控制方面的已发表的分析进展.
- 报道自第22届国际赛车分析师和兽医会议以来的发展情况.
- 总结主要趋势并强调该领域的未来方向.
主要方法:
- 关于赛马药物和兴奋剂控制方面的已发表分析进展的综述.
- 对检测小分子和大分子药物,样本准备和替代矩阵的趋势的分析.
- 对仪器进步,药物代谢,药物动力学和内源性化合物的评估.
- 专注于基因兴奋剂检测和OMICs方法.
主要成果:
- 由于COVID-19,审查期延长至5年以上,出版范围从107增加到307.
- 关键的发展包括检测各种药物类型的进步,改进的样本准备和新的仪器应用.
- 对日益增长的威胁和围绕马体育中基因兴奋剂的研究给予了显著的关注.
- 强调了了解药物代谢,药理动力学和内源性化合物的进展.
结论:
- 分析实验室正在积极开发新的策略,以打击赛马兴奋剂和药物滥用.
- 该领域的特点是检测方法,仪器仪表和研究新出现的威胁的持续创新.
- 未来的方向包括在检测新物质和应用OMIC技术方面取得进一步的进展.
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