患有自身免疫性胃炎的儿科患者的临床特征和结果
Maya Granot1,2, Beate C Beinvogl3, Michael Schvimer2,4
1Pediatric Gastroenterology and Nutrition Unit, Edmond and Lily Safra Children's Hospital, Ramat Gan, Israel.
Journal of pediatric gastroenterology and nutrition
|July 16, 2024
概括
儿童自身免疫性胃炎通常呈现为缺铁性贫血. 密切监测是至关重要的,因为转化质的高率和胃神经内分泌瘤的潜力.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 自身免疫性疾病 自身免疫性疾病
- 胃肠道新生病 胃肠道新生病
背景情况:
- 自身免疫性胃炎 (AIG) 是一种罕见的慢性炎症性疾病.
- 儿科AIG对其自然史和长期结果的数据有限.
- 潜在的后果包括胃瘤,需要在儿科病例中进一步调查.
研究的目的:
- 描述儿科自身免疫性胃炎的临床过程和结果.
- 识别AIG儿童的关键临床表现和相关疾病.
- 评估儿科AIG的长期后果,包括转形成和新形成.
主要方法:
- 在2000年至2021年间诊断出AIG的儿科患者的多中心回顾性研究.
- AIG诊断证实通过组织学体主导性缩性胃炎,有或没有阳性抗parietal细胞 (APCA) 或抗内在因子 (IF) 抗体.
- 数据收集包括人口统计,临床,实验室,内镜和组织学发现,以及随访信息.
主要成果:
- 确定了33名儿科患者 (69.7%为女性,中位数年龄为12.0岁).
- 缺铁性贫血是最常见的表现 (75%).
- 观察到高度的转质形成 (24%在诊断时,33%在随访期间发展) 和一个胃神经内分泌瘤;没有观察到内镜或组织学改善.
结论:
- 在患有自身免疫和耐火性缺铁性贫血的儿科患者中,应考虑自身免疫性胃炎.
- 杆菌感染似乎与儿科AIG无关.
- 显著的基质形成率和神经内分泌瘤的发生率强调了对儿科AIG的警监测的必要性.
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