抑制LOXL2可以改善肺动脉重塑在肺高血压

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Updated: Jun 21, 2025

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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Jochen Steppan1, Huilei Wang2, Kavitha Nandakumar1

  • 1Department of Anesthesiology and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States.

American journal of physiology. Lung cellular and molecular physiology
|July 16, 2024
PubMed
概括

肺动脉硬化是肺动脉高血压 (PAH) 的关键因素,由类似2 (LOXL2) 的lysyl氧化酶驱动. 在PH模型中,用PAT-1251抑制LOXL2可以改善肺动脉功能和生存.

关键词:
在LOXL2中使用LOXL2.肺动脉高血压 肺动脉高血压肺高血压是一种肺高血压.血管硬度 血管硬度

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