寄生病导致了内脏莱什曼病病例的严重程度

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Cássio Marinho Campelo¹, Andres Christopher Medvedovsky², Pablo Eliak Linhares de Holanda³

¹Department of Pathology and Legal Medicine, Biomedicine Center, Federal University of Ceará/Brazil, Coronel Nunes de Melo Street 1312, Rodolfo Teófilo, Fortaleza, Ceará 60430-270 Brazil.

Indian journal of microbiology

|July 16, 2024

概括

寄生虫病,即血液中寄生虫的存在,与内脏莱什曼病 (VL) 的更糟糕的临床结果有关. 寄生虫水平较高,特别是在老年人和艾滋病毒同时感染的人群中,表明VL患者的预后较差.

科学领域:

医学寄生虫学医学寄生虫学
传染性疾病传染性疾病
临床预后临床预后

背景情况:

内脏莱什曼病 (Visceral leishmaniasis,简称VL) 是一种严重的寄生虫病,由莱什曼病 (Leishmania) 种所引起.
寄生病,寄生虫在宿主中的水平,是VL临床严重性的潜在指标.
了解影响VL预后的因素对于患者管理至关重要.

研究的目的:

调查寄生病水平与被诊断患有内脏莱什曼病的个体的临床预后之间的相关性.
评估年龄和艾滋病毒同时感染对寄生病和VL结局的影响.

主要方法:

用分子方法分析来自VL患者的血液和骨髓样本,以量化寄生虫负担.
根据死亡风险的验证临床得分模型对患者进行分类.
在不同年龄组和患有或没有艾滋病毒同时感染的患者中,对寄生虫血症水平的比较.

主要成果:

与血液相比,骨髓中的寄生病显著增加.
51-64岁的个体,特别是那些同时感染艾滋病毒的人,表现出更高的寄生素血量和更糟糕的预后.
在51-64岁年龄组的严重病例中观察到白细胞和中性粒细胞数量较低.

结论:

通过血液和骨髓的分子生物学测量,寄生病是内脏莱什曼病的不良临床预后的重要预测因素.
年龄和艾滋病毒联合感染是与增加寄生虫病和VL更糟糕的结果相关的关键因素.
寄生病的量化可以帮助风险分层和VL患者的临床管理.

关键词:

临床预后临床预后寄生病的寄生病症是什么疾病的严重程度疾病的严重程度内脏莱什曼病 - - 内脏莱什曼病

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