血管瘤与卡萨巴赫·梅里特现象用类固醇和温克里斯治疗:一项回顾性研究
Pulkit Agarwal1, Sanjeev Khera2, Subhash Chandra Shaw2
1Department of Pediatrics, Military Hospital, Yol, Himachal Pradesh India.
概括
温克里斯和类固醇有效地治疗婴儿的血管瘤与卡萨巴赫-梅里特现象. 这种组合疗法在小队列中显示出显著的响应率和可管理的副作用.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 血管生物学 血管生物学
背景情况:
- 与卡萨巴赫-梅里特现象 (KMP) 相关的血管瘤 (VT) 是一种罕见且具有攻击性的儿科瘤.
- 有限的基于证据的指导方针存在于管理VT与KMP,需要进一步研究有效的治疗策略.
研究的目的:
- 评估对诊断为症状性血管瘤和卡萨巴赫-梅里特现象的婴儿使用温克里斯和类固醇联合治疗的疗效和安全性.
- 分析这个特定患者群体中各种表现和治疗反应.
主要方法:
- 进行了一项追溯观察性研究,对5名婴儿 (0-7个月) 进行了追溯观察,这些婴儿有症状/变形迅速增长的VT和KMP.
- 患者每天接受普雷迪尼索隆和每周接受温克里斯. 从患者档案中收集了有关人口统计,治疗和结果的数据.
- 响应标准包括完全响应 (CR) 和部分响应 (PR),基于瘤回归和凝血病和血栓塞缩的正常化.
主要成果:
- 五分之四的婴儿在治疗两个月内实现了部分反应 (PR).
- 另外,两名婴儿还获得了对组合治疗的完全响应 (CR).
- 在9-32个月的随访期间,没有发现显著的不良影响.
结论:
- 使用类固醇和温克里斯的组合疗法在婴儿的卡萨巴赫-梅里特现象的血管瘤管理中显示出有效性和有利的安全性.
- 这种治疗方法在缺乏这种罕见疾病的确立治疗指南的情况下提供了一个可行的选择.
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