全脑辐射疗法加上对乳腺癌脑转移的同时综合增强
Hongyan Zhang1, Qiuji Wu1, Li Li1
1Department of Radiation and Medical Oncology, Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, China.
PeerJ
|July 16, 2024
概括
全脑辐射疗法 (WBRT) 与同时集成增强 (SIB) 改善了瘤控制和乳腺癌患者的大脑转移的结果. 这种方法在治疗大脑病变方面显示出显著的临床益处.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 辐射疗法 辐射疗法
背景情况:
- 全脑辐射疗法 (WBRT) 与乳腺癌大脑转移的同时整合增强 (SIB) 疗法的疗效仍未得到充分研究.
- 大脑转移是乳腺癌管理的一个重大挑战,需要有效的治疗策略.
研究的目的:
- 评估强度调节放射治疗 (IMRT) -SIB的低分离WBRT在患有脑转移的乳腺癌患者的临床结果.
- 为了确定预后因素,并分析治疗失败模式在这个患者队列.
主要方法:
- 对27名患有脑转移的乳腺癌患者进行了回顾性分析,这些患者接受过低分离WBRT和IMRT-SIB治疗.
- 评估临床反应,无脑进展生存率,总生存率和治疗失败的模式.
主要成果:
- 在66.7%的可评估患者中,观察到客观反应率 (完整和部分).
- 平均无脑进展生存时间为8.60个月,平均整体生存时间为16.8个月.
- 治疗失败发生在现场,现场外或两者兼而有之,表明需要仔细规划治疗.
结论:
- 全脑辐射疗法 (WBRT) 加同步综合增强 (SIB) 表明,改善了脑转移的乳腺癌患者的瘤控制和临床结果.
- 这种联合放射疗法方法为在这个人群中管理内疾病提供了一个有前途的策略.
相关概念视频
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).


