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如何使质母细胞瘤对temozolomide化疗敏感:以差距为中心的观点

Alila Miramova1, Anton Gartner1,2,3, Dmitri Ivanov3

  • 1Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.

Frontiers in cell and developmental biology
|July 16, 2024
PubMed
概括

对质母细胞瘤的Temozolomide (TMZ) 化疗面临阻力. 针对DNA修复途径,如那些涉及MGMT和MMR的途径,以及PARP抑制剂,可以通过创建有毒的DNA空白来重新使瘤对TMZ敏感.

关键词:
这是一种PARP抑制剂.化学疗法 化疗 化疗质母细胞瘤是一种质母细胞瘤.不匹配的维修 维修不匹配的维修在 ssDNA 中存在差距.泰莫索洛米德 (temozolomide) 是一种有毒的物质.

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