使用骨矿物质表面密度来调整慢性疾病中的骨质量: Thalassemia 是一个例子
Mohammad-Reza Mohajeri-Tehrani1, Hadis Gerami1, Sara Shirazi2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital, North kargar Avenue, Tehran, Iran.
Caspian journal of internal medicine
|July 16, 2024
概括
骨矿物质表面密度 (BMAD) 有助于解释血症儿童的骨密度,使大腿骨矿物质密度 (BMD) 的结果正常化. 然而,与健康儿童相比,血症患者的脊椎BMD和BMAD仍然显着较低.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 医疗成像医学成像
背景情况:
- 低骨矿物质密度 (BMD) 在主要的血病患者中很普遍.
- 双能X射线吸收计 (DXA) 在评估慢性疾病儿童的骨密度方面存在挑战,原因是骨尺寸较小.
- 骨矿物表面密度 (BMAD) 提供了一个潜在的解决方案来解释骨大小的变化.
研究的目的:
- 评估BMAD在解决骨大小对乳沙血症儿童BMD测量影响方面的实用性.
- 为了比较thalassemic儿童和健康儿科队列之间的BMD和BMAD值.
主要方法:
- 研究了一组110名被诊断患有thalassemia的儿童 (73名男性,平均年龄9.6±4.3岁).
- 骨矿物质密度 (BMD) 使用双能X射线吸收计 (DXA) 进行测量.
- 计算了骨矿物质表面密度 (BMAD),并将结果与健康的伊朗儿童进行了比较.
主要成果:
- 与对照人群相比,thalassemic患者的股骨BMD (P=0.003) 和脊椎BMD (P<0.001) 和BMAD (P<0.001) 显著降低.
- thalassemic患者的股骨 BMAD 与健康儿童的 BMAD 并没有显著不同.
- 脊柱BMD和BMAD在血患者中仍然显著较低,即使在调整骨大小后.
结论:
- BMAD有效地纠正骨大小,使骨BMD在血病患者和健康儿童之间的差异正常化.
- BMAD 是一个有用的工具,用于解释部DXA扫描在患有血症的儿科患者.
- BMAD并不能完全解释在患有thalassemia的儿童中观察到的脊柱骨密度差异,这表明脊柱骨损失持续存在.
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