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克拉:一种用于疼痛医生的初级书籍
Trent Emerick1, Shravani Durbhakula2, Maria R Eibel1
1UPMC Department of Anesthesiology and Perioperative Medicine, Pittsburgh, Pennsylvania.
Current opinion in anaesthesiology
|July 16, 2024
概括
克拉用于疼痛和阿片类药物戒断,具有重大风险. 医生必须理解 kratom 的含义.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 疼痛管理 疼痛管理
背景情况:
- 克拉在美国经常用于治疗疼痛,阿片类药物戒断和疲劳.
- 它作为替代传统治疗阿片类药物使用障碍的替代方法的使用是常见的.
- 对于疼痛管理医生来说,由于风险,全面的理解至关重要.
研究的目的:
- 为疼痛管理医生提供关于 kratom 的全面讨论.
- 要突出与 kratom 使用相关的风险和潜在相互作用.
- 为了告知临床决策有关kratom作为辅助疗法.
主要方法:
- 关于 kratom 药理学和临床使用的当前文献的综述.
- 对kratom的受体结合特征和代谢物活性进行分析.
- 检查报告的不良事件和毒理学发现.
主要成果:
- 克拉及其代谢物 (mitragynine,7-OH-mitragynine) 与片受体相互作用,但不是经典的阿片类药物.
- Kratom 使用可以导致耐受性,依赖性和戒断,尽管通常不如传统阿片类药物严重.
- 有关重金属和毒素的污染存在担忧,可能导致严重的并发症,如发作和死亡.
结论:
- 克拉作为治疗疼痛的阿片类药物缓解剂的使用与相当大的风险有关.
- 疼痛医生必须意识到 kratom 的副作用和潜在的并发症.
- 在考虑Kratom在多式疼痛治疗中时,知情的临床判断至关重要.
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