RANO 2.0标准:适用于神经放射科医生的临床实践的概念
Francesco Sanvito1, Antonella Castellano2, Timothy F Cloughesy3
1UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California Los Angeles, Los Angeles, California, USA.
Current opinion in oncology
|July 16, 2024
概括
更新的神经瘤学响应评估 (RANO) 2.0标准增强了中枢神经系统质瘤治疗响应评估. 关键更新支持使用放射后MRI作为基线,并通过确认扫描验证进展,以改善临床实践.
科学领域:
- 神经瘤学神经瘤学
- 放射学 放射学是一门学科.
- 临床试验 临床试验
背景情况:
- 在临床试验中,对中枢神经系统 (CNS) 质瘤治疗反应的标准化评估至关重要.
- 现有的标准需要更新,以反映成像和理解质瘤生物学方面的进步.
研究的目的:
- 审查支持更新的神经瘤学响应评估 (RANO) 2.0标准的证据.
- 讨论RANO 2.0概念在临床实践中的适用性,特别是在放射性读取中.
主要方法:
- 最近临床试验中的多中心数据的回顾性分析.
- 审查支持RANO 2.0更新的证据.
- 讨论RANO 2.0概念的临床适用性.
主要成果:
- RANO 2.0 建议使用放射后疗法 (RT) MRI 作为后续扫描的基线.
- 建议在RT后三个月内进行确认扫描,如果放射性发现表明进展,建议进行确认扫描.
- 对于低度质瘤,鼓励进行体积测量评估;对于质母细胞瘤,非增强性疾病的评估不那么重要.
结论:
- RANO 2.0标准旨在在中枢神经系统质瘤临床试验中标准化反应评估.
- 选择的RANO 2.0概念显示出改善临床环境中患者管理的潜力.
- 在临床放射性读取中,定性评估和患者特异性因素仍然很重要.
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