右心室 - 肺动脉合和心力衰竭的结果与保存的喷射分数
Jia Wang1, Xiang Li2, Jiahui Jiang2
1Emergency Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
通过TAPSE/PASP测量的右心室-肺动脉合 (RVPAC) 是心力衰竭的关键危险因素,其中包括保留射出分数 (HFpEF). 下RVPAC独立预测HFpEF患者的死亡或住院.
科学领域:
- 心脏病学 心脏病学
- 肺高血压是什么意思 肺高血压
- 心脏衰竭研究研究
背景情况:
- 右心室-肺动脉合 (RVPAC) 描述了右心室功能和肺动脉压力之间的关系.
- 三环状平面缩外流 (TAPSE) 与肺动脉缩压 (PASP) 的比率是拟议的一种非侵入性RVPAC测量方法.
- 在心力衰竭中,RVPAC尚未被广泛研究,其中保留了喷射分数 (HFpEF).
研究的目的:
- 调查RVPAC作为HFpEF患者风险因素的实用性.
- 评估TAPSE/PASP与HFpEF中的临床结果之间的关联.
- 为了确定RVPAC是否是HFpEF中的独立预后标志物.
主要方法:
- 从2016年1月到2017年1月,对414名高高压pEF患者进行了回顾性分析.
- 评估TAPSE/PASP指数与临床指标之间的相关性.
- 5年的随访评估结果,包括所有原因的死亡和与HF相关的住院治疗.
主要成果:
- 与幸存者相比,非幸存者表现出明显较低的TAPSE和TAPSE/PASP,以及较高的PASP (p < 0.0001).
- 预测所有原因死亡的最佳切线是:TAPSE 16.5 mm,PASP 37.5 mmHg,和RVPAC 0.45 mm/mmHg.
- RVPAC独立地与所有原因死亡或与HF相关的复发住院治疗的复合终点相关 (HR: 0.006; p < 0.001).
结论:
- 由TAPSE/PASP评估的RVPAC反映了HFpEF中的一个关键风险因素.
- 这种RVPAC比率是HFpEF患者不良结果的独立预测指标.
- RVPAC测量为HFpEF管理提供了有价值的预后信息.
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