在中风后抑郁症中curculigoside的治疗潜力:专注于海马神经发生和线粒体功能
Ning-Xi Zeng1,2, Xin Chen2, Xiao-Yan Yang2
1Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
The Journal of pharmacy and pharmacology
|July 16, 2024
概括
库尔库利戈通过改善大鼠海马神经发生和线粒体功能,显示出治疗中风后抑郁症 (PSD) 的潜力. 这种天然化合物可能为PSD患者提供一种新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 脑卒中后抑郁症 (PSD) 是中风后的常见并发症,严重影响患者的康复和生活质量.
- PSD的潜在机制涉及复杂的相互作用,包括神经炎症,神经生成功能障碍和能量代谢受损.
- 目前PSD的治疗选择有限,突出显示需要新的治疗策略.
研究的目的:
- 研究curculigoside对中风后抑郁症 (PSD) 的治疗作用.
- 阐明curculigoside发挥其作用的机制,重点关注海马神经发生和线粒体氧化酸化 (OxPhos).
主要方法:
- 通过双边常见动脉阻塞和慢性不可预测的轻度压力建立了PSD的老鼠模型.
- 在体内研究评估了使用curculigoside治疗的PSD大鼠的行为变化,海马神经发生和线粒体OxPhos.
- 在体外研究中使用了类似PSD的神经干细胞 (NSC) 模型 (氧气-葡萄糖剥夺/恢复 + 皮质) 来评估curculigoside对NSC增殖,分化和线粒体功能的影响.
主要成果:
- 患PSD的老鼠表现出抑郁行为,海马神经发生障碍,海马ATP水平降低,线粒体OxPhos.降低.
- 库尔库利戈治疗显著改善了抑郁行为,并恢复了PSD大鼠的海马神经发生.
- 库尔库利戈增强了线粒体OxPhos,增加了TFAM和PGC-1α的表达,并保护NSC免受OGD/R+CORT诱导的损伤.
结论:
- 在PSD的老鼠模型中,curculigoside有效地改善了抑郁行为.
- curculigoside的治疗作用归因于增强海马线粒体氧化酸化和神经发生.
- 库尔库利戈oside显示出作为治疗中风后抑郁症的治疗剂的巨大潜力.
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