聚烯微塑料会引起腹,并通过ROS/METTL3通路损害肠道血管生成
Dongbin Zou1,2, Yun Yang1,3, Fengjie Ji1
1Tropical Crop Genetic Resource Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Journal of agricultural and food chemistry
|July 16, 2024
概括
饮食中的微塑料 (MP) 导致腹,并损害了断奶婴儿的肠道屏障功能. 聚烯MPs通过影响ROS/METTL3通路来降低肠道血管生成,造成健康风险.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 断奶婴儿的消化和免疫系统不成熟,增加了对腹的易感性.
- 微塑料 (MP) 是广泛存在的环境污染物,对婴儿肠道发育的影响尚不清楚.
研究的目的:
- 调查饮食中的聚乙烯MPs对断奶小猪的肠道发育的影响.
- 阐明MP诱导的肠道功能障碍背后的机制.
主要方法:
- 使用了一个断奶小猪模型,实验组被养含有150mg/kg聚烯MPs的饮食.
- 评估了肠道屏障功能,炎症,氧化应激和血管生成.
- 研究了活性氧物种 (ROS) 和甲基转移酶类3 (METTL3) 在MP毒性的作用.
主要成果:
- 聚烯MP暴露增加了腹发病率和肠道屏障功能受损.
- 国会议员诱导了肠道氧化应激和炎症.
- 观察到肠道血管生成的减少,这与通过ROS抑制METTL3表达有关.
结论:
- 饮食中的微塑料会加剧腹,并危及断奶婴儿的肠道健康.
- ROS/METTL3通路与MP诱导的肠道血管生成抑制有关.
- 聚烯MP显示对婴儿肠道发育和功能有毒影响.
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