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Updated: Jun 21, 2025

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开发用于冷保存细胞的宏分子冷保护剂

Liang Yuan1, Binlin Chen1, Kongying Zhu2

  • 1School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China.

Macromolecular rapid communications
|July 16, 2024
PubMed
概括

发现更安全,更有效的冷保存方法. 本文重点介绍了宏分子冷保护剂,它们可以保护细胞和生物物质免受结损伤,但没有传统小分子的毒性.

关键词:
(葡萄糖) 聚酸 (glyco) 是一种聚酸.化保存的方法含有基的聚合物.大分子冷保护剂是什么?它们是多种类型的聚菌体.

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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