超越高血压:检查可变血压在认知和大脑结构中的作用
Cassandra Morrison1, Michael D Oliver2,3, Farooq Kamal4,5
1Department of Psychology, Carleton University, Ottawa, Ontario, Canada.
概括
变性血压与比高血压更快的认知衰退和大脑变化有关. 管理可变血压可能有助于预防老年人痴呆症.
科学领域:
- 神经学 神经学
- 老年学是指老年学的学科.
- 心血管健康 心血管健康
背景情况:
- 高血压是痴呆症的可修改风险因素,导致40%的病例.
- 虽然高血压与认知衰退和大脑变化有关,但血压变化的长期影响不太清楚.
研究的目的:
- 研究可变血压 (BP) 与认知,大脑结构 (白质超强度,灰质和白质体积) 的纵向变化之间的关联,以及死后神经病理学.
- 为了比较正常,高和可变血压对随着时间的推移对认知和大脑健康的影响.
主要方法:
- 分析了来自RADC RUSH的4,606名参与者和来自ADNI的2,114名参与者,共计42,603名随访者.
- 参与者被分为正常,高或可变血压组.
- 线性混合模型用于评估BP,认知,大脑结构和神经病理学之间的关系.
主要成果:
- 患有可变血压的老年人表现出最快的认知衰退,其次是高血压,然后是正常的血压.
- 与高血压和正常血压相比,可变血压与灰质体积损失增加和白质超强度负担增加有关.
- 尸体分析显示,在可变和高血压组中,神经病变率高于正常血压组.
结论:
- 可变血压可能会降低对痴呆相关病理的恢复力,并且比单独高血压更容易患上痴呆症.
- 有效管理可变血压对于减少老年人群认知衰退至关重要.
- 在这两组研究中,研究结果一致,这表明可概括性.
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