预刺激参数预测了IVF-ET后怀孕结果,这些参数在患有不明原因不孕症的患者中可预测
A C Ozturk1, B Dilbaz, R Ozelci
1Zonguldak Maternity and Child Health Hospital, Zonguldak, Turkiye. azizecemre@gmail.com.
European review for medical and pharmacological sciences
|July 16, 2024
概括
试管婴儿受精-胚胎移植 (IVF-ET) 对于无法解释的不孕症是有效的. 较低的基底卵泡刺激激素 (FSH) 和较高的抗穆勒激素 (AMH) 水平与成功的IVF-ET妊娠结果有关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 辅助生殖技术 辅助生殖技术
背景情况:
- 无法解释的不孕症影响了大量寻求生育治疗的夫妇.
- 辅助生殖技术 (ART),特别是体外受精-胚胎移植 (IVF-ET),是无法解释的不孕症的主要干预措施.
- 确定IVF-ET成功的预测因素对于优化患者管理至关重要.
研究的目的:
- 为了评估接受IVF-ET的女性无法解释不育的怀孕结果.
- 确定影响该群体IVF-ET成功的临床和荷尔蒙因素.
- 确定基底卵泡刺激激素 (FSH) 和抗穆勒尔激素 (AMH) 在无法解释的不孕症中对怀孕的预测值.
主要方法:
- 在2007年至2019年期间,对789名患有不明原因不孕症的女性进行了回顾性分析,这些女性接受了IVF-ET治疗.
- 评估包括年龄,不孕症持续时间,体重指数 (BMI),基底FSH和基底AMH在内的因素.
- 统计分析以比较怀孕的患者和没有怀孕的患者之间的结果.
主要成果:
- 每个IVF-ET周期的临床怀孕率为19.8%.
- 怀孕和非怀孕组之间在年龄,不孕持续时间或BMI方面没有发现显著差异.
- 显著较低的基底FSH (p=0.001) 和显著较高的基底AMH (p=0.001) 水平与临床怀孕有关.
- 计算的截止值:AMH 3.34 ng/mL和FSH 7.26 IU/L用于预测怀孕.
结论:
- 试管婴儿 (IVF-ET) 是一种成功治疗无法解释的不孕不育的方法.
- 基底FSH和AMH水平与IVF-ET怀孕率在无法解释的不孕症中有关.
- 虽然基底FSH和AMH值不是高度敏感或特异性的,但为IVF-ET结果提供了有价值的预后信息.
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