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在COVID-19疫苗接种后异形性突发感神经听力损失:系统性审查和元分析

Lee Alper^1,2, Yahav Oron^1,2, Ophir Handzel^1,2

¹Department of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|July 16, 2024

概括

COVID-19疫苗显示没有与异形突发感神经听力损失 (ISSNHL) 的联系. 对数百万接种疫苗的人群的综合分析发现,ISSNHL发病率低于一般人群的发病率,这表明疫苗对听力健康的安全性.

科学领域:

流行病学流行病学
疫苗学疫苗学疫苗学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

异形性突发感神经听力损失 (ISSNHL) 是一种关键的耳部紧急情况.
人们对接种COVID-19疫苗后可能发生的不良事件表示担忧,包括对听力的影响.

研究的目的:

进行综合分析,调查COVID-19疫苗接种与ISSNHL发病率之间的关联.
为了将接种疫苗的人群中的ISSNHL发病率与一般人群中确定的发病率进行比较.

主要方法:

从2020年1月到2024年1月,在Medline (PubMed),EMBASE和谷歌学者中进行了系统的文献搜索.
包括的研究报告了接受COVID-19疫苗的人群中的ISSNHL发病率. 质量评估使用了纽卡斯尔-太华尺度.

主要成果:

综合了涉及超过1.91亿8千万名患者和2.83亿剂疫苗的三个出版物.
在COVID-19疫苗接种者中,ISSNHL的综合发病率为每10万人1.2588 (95%CI:0.1385-3.4836).
这种发生率明显低于美国 (5-27/100,000/年) 和欧盟 (60/100,000/年) 报告的发生率.

结论:

目前的证据不支持COVID-19疫苗接种与ISSNHL发病率增加之间的关联.
接种疫苗的人群中ISSNHL的发病率明显低于未接种疫苗的人群,这表明疫苗对听力安全.

关键词:

在 COVID-19 疫情中,异形性突然的感官神经神经听力损失.免疫接种免疫接种突然的耳聋是什么意思疫苗疫苗疫苗疫苗

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