抵抗训练在结肠癌化疗期间对身体功能的影响
Justin C Brown1,2,3, Shengping Yang1, Stephanie L E Compton1
1Pennington Biomedical Research Center, Baton Rouge, LA, USA.
JNCI cancer spectrum
|July 16, 2024
概括
在家庭进行抵抗训练并没有阻止接受化疗的结肠癌幸存者的身体功能下降. 与对关键体能表现指标的通常照顾相比,这种干预措施没有显著的好处.
科学领域:
- 在瘤学瘤学.
- 运动科学 运动科学
- 老年病的医生 老年病的医生
背景情况:
- 化疗经常导致身体功能下降,影响结肠癌幸存者的生活质量和生存.
- 抵抗训练在缓解化疗诱导的身体衰退的有效性仍在调查中.
研究的目的:
- 为了确定家庭抵抗训练是否可以在化疗期间预防结肠癌幸存者的身体功能下降.
- 评估力量训练对各种身体功能结果的影响.
主要方法:
- 一个多中心试验随机选择了181名接受化疗的结肠癌幸存者,他们接受了家庭抵抗训练或常规护理.
- 使用短物理性能电池 (SPPB),同度握力强度和SF-36物理功能子级别来评估身体功能.
- 用于重复测量的混合效应模型来分析随时间变化的身体功能.
主要成果:
- 与常规护理相比,抵抗训练并没有显著改善复合SPPB得分,平衡,步行速度或坐立性能.
- 同等度握力和自我报告的身体功能也没有显著改善抵抗训练.
- 基线SPPB平衡和手握强度与化疗剂量强度相关.
结论:
- 家庭抵抗训练在预防结肠癌幸存者在化疗期间身体功能相对较高的基线身体功能下降方面没有效果.
- 可能需要进一步的研究来探索在这个患者群体中维持身体功能的替代性或辅助性干预措施.
更多相关视频
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.6K
08:55The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
16.2K
相关概念视频
Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Exercise and Muscle Performance
1.4K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.4K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
