Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association between surgically treated knee injury and knee arthroplasty: an explorative study based on Finnish nationwide register-based data.

Acta orthopaedica·2026
Same author

Association of coffee intake with body composition in an older adult study population in Finland.

International journal of food sciences and nutrition·2026
Same author

Risk factors for manipulation under anesthesia after total knee arthroplasty and subsequent revision arthroplasty: a Finnish register-based study of 154,883 patients.

Acta orthopaedica·2026
Same author

Multimodal characterization of articular cartilage degeneration in the humeral head using Raman spectroscopy, biomechanics, and imaging.

Osteoarthritis and cartilage·2026
Same author

Author response to OSIN-D-25-02548 towards a socially-informed fracture-prevention agenda: expanding the lens beyond epidemiology.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

Proteomics Analysis Reveals Serum Biomarkers Reflecting Joint Pain and Physical Limitations in Knee Osteoarthritis Before and After Joint Replacement Surgery.

Cartilage·2026

相关实验视频

Updated: Jun 21, 2025

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
09:02

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Published on: August 10, 2020

7.5K

通过纳米粒子扩散成像揭示详细的软骨功能:计算机断层扫描和有限元素研究

Juuso Tuppurainen1,2, Petri Paakkari3,4, Jiri Jäntti3,4

  • 1Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland. juuso.tuppurainen@uef.fi.

Annals of biomedical engineering
|July 16, 2024
PubMed
概括

一种新的纳米粒子对比增强计算机断层扫描 (CECT) 方法可以准确预测软骨的生物机械性质. 这项技术增强了用于个性化诊断和治疗软骨疾病的计算模型.

关键词:
计算建模计算建模组成部分特定的行为.与对比度增强的计算机断层扫描.双对比剂是一种双对比剂.骨关节炎是一种骨关节炎.光子计数探测器的探测器

更多相关视频

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

6.2K
Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

983

相关实验视频

Last Updated: Jun 21, 2025

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
09:02

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Published on: August 10, 2020

7.5K
An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage
07:57

An Experimental and Finite Element Protocol to Investigate the Transport of Neutral and Charged Solutes across Articular Cartilage

Published on: April 23, 2017

6.2K
Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants
08:06

Addressing Practical Issues in Atomic Force Microscopy-Based Micro-Indentation on Human Articular Cartilage Explants

Published on: October 28, 2022

983

科学领域:

  • 生物医学工程 生物医学工程
  • 整形外科 整形外科 整形外科
  • 医疗成像医学成像

背景情况:

  • 关节软骨通过其独特的结构承受机械应力.
  • 准确的生物机械模型对于理解软骨功能至关重要,但受到复杂组织分析的限制.
  • 要改善软骨建模,需要对特定成分进行分析.

研究的目的:

  • 开发和验证一种新的纳米粒子对比增强计算机断层扫描 (CECT) 方法,用于预测关节软骨的成分特异性生物机械性质.
  • 评估CECT在评估纤维状和非纤维状软骨功能和流体流动方面的能力.
  • 证明将CECT衍生性质集成到特定学科的生物力学模型中的可行性.

主要方法:

  • 马关节软骨样本 (n=60) 使用微计算机断层扫描 (μCECT) 用纳米粒子对比剂进行成像.
  • 评估了两种μCECT技术:使用氧化纳米粒子 (Ta2O5-cNP) 的常规能量整合μCECT和使用双对比剂 (Ta2O5-cNP和素) 的新型光子计数μCECT.
  • 对比剂的吸收与从纤维增强的可弹性有限元素模型中得出的软骨功能性质相关.

主要成果:

  • 该CECT方法成功地预测了关节软骨的个体成分特定的生物力学特性.
  • 图像技术证明了评估纤维状和非纤维状软骨功能的能力.
  • 使用这种方法可以评估软骨内受透性影响的液体流量.

结论:

  • 新型纳米粒子CECT提供了一种方法来确定关节软骨的组成部分特定的生物力学特性.
  • 这种技术可以评估软骨纤维状/非纤维状功能和流体动力学.
  • 将这些特性纳入生物机械模型为个性化软骨诊断和治疗策略提供了潜力.