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在乳腺癌细胞中,EPRS1的AKT依赖核定位激活了PARP1

Isaac Zin1,2, Arnab China1, Krishnendu Khan1

  • 1Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

Proceedings of the National Academy of Sciences of the United States of America
|July 16, 2024
PubMed
概括

谷氨基烯基tRNA合成酶 (EPRS1) 移动到缺乏PTEN的乳腺癌细胞的核中,在那里它调节PARP1活动,影响DNA修复和瘤生长. 这表明针对EPRS1的目标.

关键词:
在ADP-ribosylation过程中.在 AKT AKT 里面.在EPRS1中使用EPRS.PARP1 的第一部分.氨基酸-tRNA合成酶的氨基酸.

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