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肠道微生物群通过调节由丁酸盐介导的肠道屏障功能,促进肝侧侧阻塞综合征中的巨细胞M1两极化

Si Zhao¹, Han Zhang¹, Hanlong Zhu²

¹Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

|July 16, 2024

概括

肠道微生物群和巨细胞的激活会恶化罗利素类化合物诱导的肝侧侧侧阻塞综合征 (PA-HSOS). 酸盐补充剂可以通过改善肠道屏障和减少M1巨细胞两极分化来提供一种新的治疗策略.

科学领域:

胃肠病学和肝病学
免疫学免疫学免疫学
微生物学微生物学

背景情况:

肠肝轴在肝脏疾病的发病过程中起着至关重要的作用.
皮罗利兹类诱导的肝侧阻塞综合征 (PA-HSOS) 是一种严重的肝脏疾病,与肠道失调和免疫激活有关.

研究的目的:

调查肠道微生物群和巨细胞激活在PA-HSOS进展中的作用.
阐明潜在的机制,并探索PA-HSOS的潜在治疗干预措施.

主要方法:

通过使用单克罗他林 (MCT) 建立了PA-HSOS的小鼠模型.
使用16S rDNA测序分析了便微生物群组成.
雇佣了巨细胞枯竭,便微生物群移植 (FMT) 和酸盐补充剂来评估关键因素.

主要成果:

在PA-HSOS模型中,微生物多样性减少,巨细胞被激活.
巨细胞枯竭减轻了肝炎和亡.
丁酸盐缺乏与增加的肝损伤相关,而丁酸盐的使用改善了损伤和改善了肠道屏障功能.
分别在门静脉和肝脏中观察到升高的脂多糖和M1巨细胞,在HSOS-FMT小鼠和没有酸盐治疗的小鼠中观察到.

结论:

肠道微生物群通过肠道屏障功能受损的M1巨细胞两极分化调节,加剧PA-HSOS,这是由丁酸盐缺乏引起的.
这项研究确定了针对PA-HSOS治疗的肠道微生物群和丁酸盐的新型治疗策略.

关键词:

这就是HSOS的HSOS.在M1巨细胞中.黄油酸盐黄油酸盐是一种我们的肠道微生物群.肠肝轴肠肝轴肠肝轴肠道屏障肠道屏障肠道屏障

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