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Updated: Jun 21, 2025

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开发Zalfermin,一种长效蛋白质溶解稳定FGF21类似物

Kristian Sass-Ørum1, Tina Møller Tagmose1, Jørgen Olsen1

  • 1Novo Nordisk A/S, Global Research Technologies, DK-2760 Maaloev, Denmark.

Journal of medicinal chemistry
|July 16, 2024
PubMed
概括

扎尔弗林是一种新型纤维细胞生长因子21 (FGF21) 模拟剂,是为了提高稳定性和有效性而设计的. 这种蛋白质修饰策略导致一种强大的类似物用于治疗与代谢功能障碍相关的脂肪肝炎.

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Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
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