对健康的大丹麦人和大丹麦人患有扩张性心肌病的右心室功能的评估
E Mederska1, H Stephenson2, T W Maddox1
1Small Animal Teaching Hospital, Department of Small Animal Clinical Sciences, School of Veterinary Science, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire CH64 7TE, UK.
概括
右心室 (RV) 功能障碍随着大丹麦人扩张性心肌病 (DCM) 的进展而恶化. 像RV纵向应变 (RVLS) 和部分面积变化 (FAC) 这样的心声指标显示受影响的狗的RV缩功能受损.
科学领域:
- 心脏病学 心脏病学
- 兽医医学 兽医医学 兽医医学
- 狗的健康 狗的健康
背景情况:
- 右心室 (RV) 功能障碍是人类扩张性心肌病 (DCM) 的关键预后因素.
- 巨型品种狗,特别是大丹麦犬 (GDs) 的RV功能存在有限的参考值,因为依赖体重的指数.
- 这项研究解决了在不同DCM阶段的GD中对RV功能评估的需求.
研究的目的:
- 为了比较正常大丹麦人 (GDs) 的RV功能回声心脏学指数.
- 为了评估GDs与临床前DCM (PC-DCM) 的VR功能.
- 评估DCM和充血性心力衰竭 (DCM-CHF) 的GD中的RV功能.
主要方法:
- 一项对116家客户拥有的成年GD (74个正常,31个PC-DCM,11个DCM-CHF) 的回顾性队列研究.
- 对RV功能的心声评估包括RV纵向应变 (RVLS),应变速率,部分面积变化 (FAC),三环状平面缩外流 (TAPSE) 和组织多普勒成像 (TDI S').
- 统计分析以确定DCM状态和RV功能指数之间的关系.
主要成果:
- 与健康对照相比,PC-DCM和DCM-CHF的狗中TAPSE,FAC和TDI S'显著下降.
- 在DCM-CHF犬群中,FAC的水平低于PC-DCM犬群.
- 在DCM-CHF犬群中,RVLS损伤更明显,RVLS在区分正常与DCM-CHF犬群中表现出高准确性.
结论:
- 随着GD中DCM的进步,心声视频功能指数 (TAPSE,FAC,TDI S',RVLS,张力率) 逐渐恶化.
- 这些发现表明受DCM影响的GDs的RV缩功能受损.
- 这项研究强调了特定的心声回声学参数的有用性,以评估该品种的RV健康状况.
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