由免疫检查点抑制剂引起的甲状腺功能障碍改善了癌症的结果
Marta García-Goñi1, Beatriz Vázquez Gutiérrez1, Miguel F Sanmamed2
1Department of Endocrinology and Nutrition, University of Navarra, Pamplona, Spain.
Endocrine-related cancer
|July 16, 2024
概括
免疫检查点抑制剂 (ICI) 可以导致甲状腺功能障碍与免疫相关的不良事件 (TD-irAEs). 癌症患者的TD-irAEs与更好的治疗反应和更长的存活时间有关,这表明它可能具有积极的预后作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 免疫检查点抑制剂 (ICI) 正在彻底改变癌症治疗.
- 与免疫相关的不良事件 (irAEs) 在ICI中很常见.
- 甲状腺功能障碍 (TD-irAEs) 是一个常见的irAE,但其预后意义尚不清楚.
研究的目的:
- 在接受ICI的癌症患者中研究TD-irAEs的特征.
- 评估TD-irAEs与临床结果之间的关联,包括反应和生存.
主要方法:
- 对238名用ICI治疗的癌症患者的单中心回顾性分析.
- 评估TD-irAE发病率,时间和与客观反应率 (ORR) 和整体存活率 (OS) 的关联.
- 使用多变量调整回归和考克斯比例危险模型.
主要成果:
- 近30%的患者患有TD-irAEs,在组合治疗中发病率更高.
- 患有TD-irAEs的患者表现出明显更高的ORR (60%vs42.3%) 和更长的OS (45vs16个月).
- TD-irAEs独立地与进展风险 (77%) 和死亡率 (47%) 的降低有关.
结论:
- 在接受ICI治疗的患者中,TD-irAEs是常见的.
- 发展TD-irAEs似乎是一个有利的预后标志物,与改善的治疗反应和生存有关.
- 进一步的研究是有必要的,以了解潜在的机制和临床影响.
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