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Updated: Oct 27, 2025

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深度突变扫描揭示了拉萨病毒葡萄糖蛋白复合体的功能约束和抗体逃脱潜力

Caleb R Carr1, Katharine H D Crawford1, Michael Murphy2

  • 1Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA.

Immunity
|July 16, 2024
PubMed
概括

拉萨病毒的进化影响了疫苗和抗体的设计. 了解其糖蛋白复合体 (GPC) 中的突变是开发有效的拉萨病毒疗法和疫苗的关键.

关键词:
有没有阿尔维鲁马布.阿雷维鲁马布-3的使用情况在GPC中,GPC是GPC.拉萨病毒 拉萨病毒抗体逃脱可以通过抗体逃脱.抗原变异是一种抗原变异.竞技场病毒 竞技场病毒深度突变扫描 (deep mutational scanning) 是一种对突变进行深度扫描的方法.全球流行病的流行病.

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