神经性买limia选择性地重塑了与认知情感整合相关的前部岛屿子区域的结构和内在功能
Weihua Li1, Yiling Wang1, Jiani Wang1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing 100050, China.
Journal of affective disorders
|July 16, 2024
概括
神经性Bulimia nervosa (BN) 与前脑岛的结构和功能性大脑变化有关. 特定的亚区域异常,特别是腹前岛 (vAI),可能表明BN病理生理学,并告知治疗.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
背景情况:
- 前半岛对认知控制和情绪调节至关重要.
- 前部岛膜异常与神经性吃 (BN) 有关.
- 具体的次区域对BN的贡献仍然不清楚.
研究的目的:
- 为了研究与健康对照组相比,BN患者前部岛屿子区域的结构和功能差异.
- 探索神经成像发现与BN中的临床特征之间的相关性.
主要方法:
- 结构性MRI和休息状态功能性MRI数据来自54名BN患者和56名健康对照.
- 基于voxel的形态测量,低频波动的幅度 (ALFF) 和基于种子的功能连接性 (FC) 分析前岛子区域.
- 神经成像结果与BN临床特征之间的相关性分析.
主要成果:
- 在BN患者中,右背前胰岛 (dAI) 和双侧腹前胰岛 (vAI) 的灰质体积减少.
- 在BN患者中观察到双边dAI缓慢-5频段的ALFF降低.
- 在双边dAI和precuneus/superior frontal gyri之间,以及双边vAI和 cingulate区域之间发现了改变的FC,与BN严重程度和饮食行为相关联.
结论:
- 前部岛屿子区域的功能分离与BN病理生理学有关.
- 涉及情绪处理的腹部前部岛屿 (vAI) 显示出作为BN的神经成像生物标志物的潜力.
- 结果可能会为BN的治疗策略提供信息.
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