在慢性精神分裂症中,肠道菌群失调与相关的炎症激活有关
Xiuxia Yuan1, Xue Li1, Gangrui Hei1
1Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan International Joint Laboratory of Biological Psychiatry, Zhengzhou, China; Henan Psychiatric Transformation Research Key Laboratory, Zhengzhou University, Zhengzhou, China.
Behavioural brain research
|July 16, 2024
概括
精神分裂症 (SCZ) 与肠道真菌 (菌群) 的变化有关. 菌群生物失调,慢性炎症和肠道屏障受损与SCZ有关,影响代谢物和症状.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 肠-大脑轴与精神分裂症 (SCZ) 有关.
- 肠道菌群在SCZ中的作用仍未得到充分研究.
- 以前的研究强调了肠道微生物对心理健康的影响.
研究的目的:
- 研究慢性SCZ患者的肠道菌群,便代谢物和临床症状之间的关联.
- 在SCZ中探索真菌菌群失生症,慢性炎症和肠道屏障功能之间的关系.
主要方法:
- 一项为期半年的随访研究,对109名SCZ患者和77名健康对照进行了随访.
- 使用内部转录间隔器 (ITS) 测序进行肠道菌群分析.
- 通过非向液体染色体质谱法 (LC-MS) 进行便代谢物质分析.
- 使用阳性和阴性综合征量表 (PANSS) 评估症状严重程度.
主要成果:
- 坎迪达型肠型与增加的积极症状和抑郁症相关.
- 菌生物失调与与炎症和神经递质通路相关的便代谢物发生变化有关.
- 在真菌生物组成和便代谢物之间发现了显著的相关性 (Procrustes分析).
- 肠道屏障功能受损,以高的D-乳酸盐和降低的Mucin 2水平表示.
- 血清TNF-α水平增加表明SCZ患者的慢性炎症.
结论:
- 在SCZ中,mycobiota失生有助于慢性炎症和肠道屏障受损.
- 这些变化与SCZ的特定代谢变化和临床症状有关.
- 向菌群和肠道炎症可能为SCZ提供新的治疗策略.
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